Table of Contents: Oncotarget’s Volume 12, Issue #23

Read short summaries of the latest oncology-focused research published in this week’s issue of Oncotarget: Volume 12, Issue 23.

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Cover (Research Paper): Anaplastic lymphoma kinase rearrangement prevalence in patients with advanced non-small cell lung cancer in the United States – retrospective real world data

Origin: Mississippi, California, Indiana, New Jersey, Texas, Maryland, United States; Beijing, China

Institutions: University of Mississippi Medical Center, Roche Information Solutions, Roche Diagnostics Corporation, Genesis Research, Houston Methodist Hospital

Quote: “This study assessed the prevalence of anaplastic lymphoma kinase (ALK) rearrangements in US oncology practices.”

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News: Excitement for our future

Origin: Washington, DC, United States

Institution: Georgetown University Medical Center

Quote: “News on: Opposing effects of BRCA1 mRNA expression on patient survival in breast and colorectal cancer and variations among African American, Asian, and younger patients by Leaf et al. Oncotarget. 2021; 12:1992–2005. https://doi.org/10.18632/oncotarget.28082. [PubMed]”

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Editorial Paper: Interferon-γ/IRF-1 pathway regulatory mechanisms of PD-L1 expression and relevance for immune checkpoint blockade in hepatocellular carcinoma (HCC)

Origin: Pennsylvania, United States

Institution: University of Pittsburgh Medical Center

Quote: “Among all immune checkpoints, the PD-L1/PD-1 axis has been confirmed as therapeutic target in many malignancies from clinical trials of immune checkpoint blockade (ICB) alone or in combination with other therapeutics. The recent IMbrave150 clinic trial combining atezolizumab with bevacizumab shows encouraging antitumor activity in patients with unresectable hepatocellular carcinoma (HCC) [2].”

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Editorial Paper: Results from a randomized trial combining trastuzumab with a peptide vaccine suggest a role for HER2-targeted therapy in triple-negative breast cancer

Origin: Florida, United States

Institution: Brooke Army Medical Center

Quote: “Preclinical data allude to a synergistic effect of HER2-targeted therapy, with or without concomitant cytotoxic chemotherapy, when combined with either checkpoint inhibitors, or cancer vaccine immunotherapy [3–6].”

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Click here to read Oncotarget’s Volume 12, Issue #23.

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